Association of response to TNF inhibitors in rheumatoid arthritis with quantitative trait loci for CD40 and CD39
Articolo
Data di Pubblicazione:
2019
Abstract:
We sought to investigate whether genetic effects on response to TNF inhibitors (TNFi) in rheumatoid arthritis (RA) could be localised by considering known genetic susceptibility loci for relevant traits and to evaluate the usefulness of these genetic loci for stratifying drug response.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
anti-tnf; pharmacogenetics; rheumatoid arthritis; Adult; Aged; Antigens, CD; Antirheumatic Agents; Apyrase; Arthritis, Rheumatoid; Biological Products; CD40 Antigens; Cohort Studies; Female; Gene Expression Regulation; Genome-Wide Association Study; Humans; Male; Middle Aged; Molecular Targeted Therapy; Multivariate Analysis; Predictive Value of Tests; Prognosis; Quantitative Trait Loci; Regression Analysis; Treatment Outcome; Tumor Necrosis Factor Inhibitors
Elenco autori:
Spiliopoulou, Athina; Colombo, Marco; Plant, Darren; Nair, Nisha; Cui, Jing; Coenen, Marieke Jh; Ikari, Katsunori; Yamanaka, Hisashi; Saevarsdottir, Saedis; Padyukov, Leonid; Bridges, S Louis; Kimberly, Robert P; Okada, Yukinori; van Riel, Piet L Cm; Wolbink, Gertjan; van der Horst-Bruinsma, Irene E; de Vries, Niek; Tak, Paul P; Ohmura, Koichiro; Canhão, Helena; Guchelaar, Henk-Jan; Huizinga, Tom Wj; Criswell, Lindsey A; Raychaudhuri, Soumya; Weinblatt, Michael E; Wilson, Anthony G; Mariette, Xavier; Isaacs, John D; Morgan, Ann W; Pitzalis, Costantino; Barton, Anne; Mckeigue, Paul
Link alla scheda completa:
Pubblicato in: