Synaptophysin expression in V600EBRAF-mutated advanced colorectal cancers identifies a new subgroup of tumours with worse prognosis
Articolo
Data di Pubblicazione:
2021
Abstract:
Neuroendocrine differentiation has been extensively associated with worse prognosis and to mechanisms of therapy resistance in several epithelial cancers. A high prevalence of neuroendocrine differentiation was recently described in V600EBRAF-mutated (BRAFmt) metastatic colorectal cancers (mCRCs) but no data are available about its prognostic impact in this setting.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
(V600E)BRAF; Colorectal cancer; Immunohistochemistry; Neuroendocrine; Prognostic markers; Synaptophysin
Elenco autori:
Fassan, Matteo; Milione, Massimo; Maddalena, Giulia; Cremolini, Chiara; Schirripa, Marta; Pietrantonio, Filippo; Pella, Nicoletta; Dell'Aquila, Emanuela; Sperti, Elisa; Zichi, Clizia; Bergamo, Francesca; Volante, Marco; Boccaccino, Alessandra; Morano, Federica; Cortiula, Francesco; De Maglio, Giovanna; Rimassa, Lorenza; Smiroldo, Valeria; Calvetti, Lorenzo; Aprile, Giuseppe; Salvatore, Lisa; Santini, Daniele; Salmaso, Roberta; Centonze, Giovanni; Biason, Paola; Borga, Chiara; Lonardi, Sara; Zagonel, Vittorina; Dei Tos, Angelo P; Di Maio, Massimo; Loupakis, Fotios
Link alla scheda completa:
Pubblicato in: