Impact of early tumor shrinkage and depth of response on the outcomes of panitumumab-based maintenance in patients with RAS wild-type metastatic colorectal cancer
Articolo
Data di Pubblicazione:
2021
Abstract:
In patients with metastatic colorectal cancer (mCRC) receiving highly active first-line combination treatments, early tumor shrinkage (ETS) and depth of response (DoR) are associated with survival, but their influence on outcomes during maintenance therapy is unknown. The Valentino study showed inferior PFS in 229 RAS wild-type mCRC patients randomized to panitumumab plus FOLFOX followed by maintenance with panitumumab vs. panitumumab + 5-FU/LV.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Depth of response; Early tumor shrinkage; Maintenance therapy; Metastatic colorectal cancer; Molecular hyper-selection; Panitumumab; RAS wild-type
Elenco autori:
Manca, Paolo; Corallo, Salvatore; Randon, Giovanni; Lonardi, Sara; Cremolini, Chiara; Rimassa, Lorenza; Bergamo, Francesca; Antoniotti, Carlotta; Smiroldo, Valeria; Zaniboni, Alberto; Murialdo, Roberto; Tampellini, Marco; Tomasello, Gianluca; Clavarezza, Matteo; Racca, Patrizia; Antista, Maria; Raimondi, Alessandra; Prisciandaro, Michele; Pagani, Filippo; Palermo, Federica; Greco, Francesca Gabriella; Vaiani, Marta; Di Bartolomeo, Maria; de Braud, Filippo; Calareso, Giuseppina; Morano, Federica; Pietrantonio, Filippo
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