Role of proton-coupled folate transporter in pemetrexed resistance of mesothelioma: clinical evidence and new pharmacological tools
Articolo
Data di Pubblicazione:
2017
Abstract:
Thymidylate synthase (TS) has a predictive role in pemetrexed treatment of mesothelioma; however, additional chemoresistance mechanisms are poorly understood. Here, we explored the role of the reduced-folate carrier (RFC/SLC19A1) and proton-coupled folate transporter (PCFT/SLC46A1) in antifolate resistance in mesothelioma.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
PCFT; expression; malignant pleural mesothelioma; methylation; outcome; pemetrexed; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Cell Proliferation; Female; Folic Acid Antagonists; Follow-Up Studies; Humans; Immunoenzyme Techniques; Male; Mesothelioma; Middle Aged; Pemetrexed; Pleural Neoplasms; Prognosis; Proton-Coupled Folate Transporter; Reduced Folate Carrier Protein; Survival Rate; Thymidylate Synthase; Tumor Cells, Cultured; Drug Resistance, Neoplasm
Elenco autori:
Giovannetti, E; Zucali, P A; Assaraf, Y G; Funel, N; Gemelli, M; Stark, M; Thunnissen, E; Hou, Z; Muller, I B; Struys, E A; Perrino, M; Jansen, G; Matherly, L H; Peters, G J
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