Comparison of rhinitis treatments using MASK-air® data and considering the minimal important difference
Articolo
Data di Pubblicazione:
2022
Abstract:
Background: Different treatments exist for allergic rhinitis (AR), including pharmacotherapy and allergen immunotherapy (AIT), but they have not been compared using direct patient data (i.e., “real-world data”). We aimed to compare AR pharmacological treatments on (i) daily symptoms, (ii) frequency of use in co-medication, (iii) visual analogue scales (VASs) on allergy symptom control considering the minimal important difference (MID) and (iv) the effect of AIT. Methods: We assessed the MASK-air® app data (May 2015–December 2020) by users self-reporting AR (16–90 years). We compared eight AR medication schemes on reported VAS of allergy symptoms, clustering data by the patient and controlling for confounding factors. We compared (i) allergy symptoms between patients with and without AIT and (ii) different drug classes used in co-medication. Results: We analysed 269,837 days from 10,860 users. Most days (52.7%) involved medication use. Median VAS levels were significantly higher in co-m...
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
allergen immunotherapy; allergic rhinitis; co-medication; multivariable mixed-effects model; real-world data;
Elenco autori:
Sousa‐pinto, Bernardo; Schunemann, Holger J.; Sá‐sousa, Ana; Vieira, Rafael ; José, ; Amaral, Rita; Anto, Josep M.; Klimek, Ludger; Czarlewski, Wienczyslawa; Mullol, Joaquim; Pfaar, Oliver; Bedbrook, Anna; Brussino, Luisa; Kvedariene, Violeta; Larenas‐linnemann, Desirée; Okamoto, Yoshitaka; Ventura, Maria Teresa; Agache, Ioana; Ansotegui, Ignacio ; Bergmann, Karl C.; Bosnic‐anticevich, Sinthia; Brozek, Jan; Canonica, G. Walter; Cardona, Victoria; Carreiro‐martins, Pedro; Casale, Thomas; Cecchi, Lorenzo; Chivato, Tomas; Chu, Derek K.; Cingi, Cemal; Costa, Elísio M.; Cruz, Alvaro A.; Del Giacco, Stefano; Devillier, Philippe; Eklund, Patrik; Fokkens, Wytske J.; Gemicioglu, Bilun; Haahtela, Tari; Ivancevich, Juan Carlos; Ispayeva, Zhanat; Jutel, Marek; Kuna, Piotr; Kaidashev, Igor; Khaitov, Musa; Kraxner, Helga; Laune, Daniel; Lipworth, Brian; Louis, Renaud; Makris, Michael; Monti, Riccardo; Morais‐almeida, Mario; Mösges, Ralph; Niedoszytko, Marek; Papadopoulos, Nikolaos G.; Patella, Vincenzo; Pham‐thi, Nhân; Regateiro, Frederico S.; Reitsma, Sietze; Rouadi, Philip W.; Samolinski, Boleslaw; Sheikh, Aziz; Sova, Milan; Todo‐bom, Ana; Taborda‐barata, Luis; Toppila‐salmi, Sanna; Sastre, Joaquin; Tsiligianni, Ioanna; Valiulis, Arunas; Vandenplas, Olivier; Wallace, Dana; Waserman, Susan; Yorgancioglu, Arzu; Zidarn, Mihaela; Zuberbier, Torsten; Fonseca, Joao A.; Bousquet, Jean
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