A BAFF/APRIL-dependent TLR3-stimulated pathway enhances the capacity of rheumatoid synovial fibroblasts to induce AID expression and Ig class-switching in B cells
Articolo
Data di Pubblicazione:
2011
Abstract:
To dissect the role of toll-like receptor (TLR) signalling and B cell survival/proliferating factors in the crosstalk between rheumatoid arthritis synovial fibroblasts (RASF) and B cells.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Aged; Arthritis, Rheumatoid; B-Cell Activating Factor; B-Lymphocytes; Coculture Techniques; Cytidine Deaminase; Female; Fibroblasts; Humans; Immunoglobulin A; Immunoglobulin Class Switching; Immunoglobulin D; Immunoglobulin G; Lymphocyte Activation; Male; Middle Aged; Osteoarthritis; Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Skin; Synovial Membrane; Toll-Like Receptor 3; Tumor Necrosis Factor Ligand Superfamily Member 13
Elenco autori:
Bombardieri, Michele; Kam, Ngar-Woon; Brentano, Fabia; Choi, Ken; Filer, Andrew; Kyburz, Diego; Mcinnes, Iain B; Gay, Steffen; Buckley, Christopher; Pitzalis, Costantino
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